项目: 1. 国家自然科学基金项目：近红外聚集诱导发光和活性氧参与的高效基因载体的构建（21674080），2017.01-2020.12，66万，主持； 2. 国家自然科学基金项目：基于beta-环糊精的反相高分子胶束的构建及其在肽类药物传输中的应用（21374079），2013.01-2017.12，83万，主持； 3. 国家自然科学基金项目：含 beta-环糊精高分子的合成、反相胶束的构建及其在肽类药物控制释放中的应用（21244004），2013.01-2013.12，10万，主持； 4. 国家自然科学基金项目：含多氢键给体的高分子的合成及其作为基因载体的性能研究（21074092），2011.01-2013.12, 35万，主持； 5. 2012年入选天津市高校“中青年骨干创新人才培养计划”2012年12月—2015年11月，45万，主持 6. 天津市自然科学基金：侧链降解型聚阳离子基因载体的合成及其性能研究（10JCYBJC26800），2010.10 - 2013.09，10万，主持； 7. 973计划前期专项：新型生物降解高分子纳米材料的合成及其环境响应性能（2009CB626612），2009.04-11.08，55万元，与南开大学马建标教授合作项目；是天津理工大学方负责人（结题）； 7. 天津市高等学校科技发展基金计划项目：羧基聚甲基丙烯酸甘油酯的合成及对阿霉素的控制释放（20090505），2009.12-2012.12，3万元，主持（结题）。 8. 教育部新世纪优秀人才支持计划，2012.01-2014.12，50万，主持； 9. 2015年入选“天津市131创新型人才培养工程”第一层次人选 论文: 1.Q. Li, Y. Wu, H. Lu, X. Wu, S. Chen, N. Song, Y.-W. Yang*, Hui Gao*, Construction of supramolecular nanoassembly for responsive bacterial elimination and effective bacterial detection, ACS Appl. Mater. Interfaces, 2017, 9, 10180-10189. 2.T. Wang, Q. Chen, H. Lu W. Li, Z. Li, J. Ma, H. Gao,* Shedding PEG palisade by temporal photo-stimulation and intracellular reducing milieu for facilitated intracellular trafficking and DNA releasing, Bioconjug. Chem.2016, 27, 1949-1957. 3.X. Q. Han, Q. X. Chen, H. G. Lu, P. Guo, W. Li, G. L. Wu, J. B. Ma, H.Gao*, Incorporation of an aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested the nuclear translocation of uncomplexed DNA, Chem. Commun., 2016, 52, 3907-3910. 4.H. Lu,* Y. Zheng, X. Zhao, L. Wang, S. Ma, X. Han, B. Xu, W. Tian, H. Gao,* Highly efficient farRed/Near-infrared solid fluorophores: aggregation-induced emission, intramolecular charge transfer, twisted molecular conformation, and bioimaging application. Angew. Chem. Int. Ed., 2016, 55, 155 -159. 5.Y. Long, W. Gu, C. Pang, J. Ma, H. Gao, * Construction of coumarin-based cross-linked micelles with pH responsive hydrazone bond and tumor targeting moiety, J. Mater. Chem .B, 2016, 4, 1480-1488. 6.C. Fan, C. Pang,* X. Liu, J. Ma, H. Gao,* Self-curing furan-based elastic thermosets derived from citric acid, Green Chem. 2016,18, 6320-6328. 7.Y. Wu, Q. Chen, Q. Li, H. Lu, X. Wu, J. Ma,H. Gao*,Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition, J. Mater. Chem. B, 2016, 4, 6350-635. 8.J. Wen, H. Lu*, D. Liu, H. Gao*, Fabrication of macroporous protein-containing films through the reverse emulsions approach featuring β-cyclodextrin-conjugated PEG-PLGA copolymers, Chinese J. Polym. Sci., 2016, 34, 730-738 9.X. Q. Han, Q. X. Chen, H. G. Lu, J. B. Ma, H. Gao* Probe Intracellular Trafficking of Polymeric DNA Delivery Vehicle by Functionalization with Aggregation-induced Emissive Tetraphenylethene Derivative, ACS Appl Mater Inter, 2015, 7, 28494-28501. 10.Q. Li, S Xu,? H. Zhou, X. Wang, B. Dong, H. Gao,* J. Tang,* Y. Yang.* pH and Glutathione Dual-Responsive Dynamic Cross-Linked Supramolecular Network on Mesoporous Silica Nanoparticles for Controlled Anticancer Drug Release, ACS Appl. Mater. Interfaces,2015, 7, 28656-28664. 11.X. Han, D. Liu, T. Wang, H. Lu, J. Ma, Q. Chen,* H. Gao,* Aggregation-induced-emissive molecule incorporated into polymeric nanoparticulate as FRET donor for observing doxorubicin delivery. ACS Appl. Mater. Interfaces, 2015, 7 (42), 23760-23766. 12.P. Guo, W. Gu, Q. Chen, H. Lu, X. Han, W. Li, H. Gao,* Dual functionalized amino poly(glycerol methacrylate) with guanidine and Schiff-base linked imidazole for enhanced gene transfection and minimized cytotoxicity. J. Mater. Chem., B, 2015, 3, 6911-6918. 13.Y. Zhuang, W. Gu, J. Yang, X. Chen, H. Gao,*Supramolecular nanoparticles constructed by balancing forces between attractive host-guest and repulsive electrostatic interactions in two positively charged polymers. RSC Adv.,2015, 5, 96464-96471. 14.Y. Wu, Y. Long, Q.-L. Li, S. Han, J. Ma, Y.-W. Yang,* H. Gao,* Layer-by-layer (LBL) self-assembled biohybrid nanomaterials for efficient antibacterial applications, ACS Appl. Mater. Interfaces,2015, 7, 17255-17263. 15.H. Gao, H. Takemoto, Q. Chen, M. Naito, H. Uchida, X. Liu, K. Miyata,* K. Kataoka,* Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity. Chem. Commun.,2015, 51, 3158-3161. 16.W.-X. Gu, Q.-L. Li, H. Lu, L. Fang, Q. Chen, Y.-W. Yang,* H. Gao,* Construction of stable polymeric vesicles based on azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery. Chem. Commun.,2015, 51, 4715-4718. 17. W.-X. Gu, M. Zhu, N. Song, X. Du, Y.-W. Yang, H. Gao,*Reverse micelles based on biocompatible β-cyclodextrin conjugated polyethylene glycol block polylactide for protein delivery. J. Mater. Chem. B,2015, 3, 316-322. 18.X Du, N. Song, Y-W Yang, G Wu, J Ma, H Gao,* Reverse micelles based on β-cyclodextrin-incorporated amphiphilic polyurethane copolymers for protein delivery. Polym. Chem. 2014, 5300-5309. (IF=5.37) 19.W Gu, Y-W Yang, J Wen, H Lu, H Gao,* Construction of reverse vesicles from pseudo-graft poly(Glycerol Methacrylate)s via cyclodextrin-cholesterol interaction. Polym. Chem.2014, 5, 6344-6349. (IF=5.37） 20.Q-L Li, L-Z Wang, X Qiu, Y-L Sun, P Wang, Y Liu, F Li, A-D Qi, H Gao,* Y-W Yang,* Stimuli-responsive biocompatible nanovalve based on β-cyclodextrin modified poly(glycidyl methacrylate). Polym. Chem.2014, 5, 3389-3395. (IF=5.37) 21.Q-L Li,W Gu, H. Gao,* Yang, Y.-W,* Self-assembly and applications of poly(glycidyl methacrylate)s and their derivatives. Chem. Commun.2014, 50, 13201-13215. (IF: 6.718) 22.L Wang, Y.-W. Yang, M. Zhu, G Qiu, G Wu, H Gao,* β-Cyclodextrin-conjugated amino poly(glycerol methacrylate)s for efficient insulin delivery. RSC Adv, 2014, 4, 6478-6485. (IF=3.70) 23.Q-L Li,Y Sun,Y -L Sun, J Wen, Y Zhou, Q Bing, L Isaacs, Y Jin, H Gao,* Y-W Yang,* Mesoporous silica nanoparticles coated by layer-by-layer self-assembly using cucurbit[7]uril for in vitro and in vivo anticancer drug release.Chem Mater, 2014, 26, 6418-6431. (IF= 8.535) 24.D-E Liu, H Han, H Lu, G Wu, Y Wang, J Ma, H Gao,* Synthesis of amphiphilic polyaspartamide derivatives and construction of reverse micelles. RSC Adv, 2014, 4, 37130-37137. (IF=3.70) 25.H Han, D -E Liu, H Lu, W-X Gu, H Gao,* Construction of micelles based on biocompatible pseudo-graft polymers via b-cyclodextrin/cholesterol interaction for protein delivery. RSC Adv, 2014, 4, 40882-40891. (IF=3.70) 26.Y Sun, Y-L Sun, L Wang, J Ma, Y-W Yang,* H Gao,* Nanoassembles constructed from mesoporous silica nanoparticles and surface-coated multilayer polyelectrolytes for controlled drug delivery. Micropor Mesopor Mater, 2014,185, 245-253. (IF=3.37) 27.Z Liang, M Zhu, Y-W Yang, H Gao,* Antimicrobial activities of polymeric quaternary ammonium salts from poly(glycidyl methacrylate)s. Polym. Adv. Technol. 2014, 25, 117-122. (IF=1.64) 28.H Gao,* Z Liang, X Wu, C Li, Y-W Yang, G. Wu, J Ma, Quaternized poly(Glycerol Methacrylate)s for enhanced pDNA delivery. 2013, J. Controlled Release, 172, e104-e105. (IF=7.26) 29.C Li, Y-W Yang, Z-X Liang, G-L Wu, H Gao,* Post-modification poly(glycidyl methacrylate)s with alkyl amine and isothiocyanate for effective pDNA delivery. Polym Chem, 2013, 4, 4366-4374. (IF=5.37) 30.Z Liang, Xi Wu, Y-W Yang, C Li, G Wu, H Gao,* Quaternized amino poly(glycerol-methacrylate)s for enhanced pDNA delivery. Polym Chem, 2013,4, 3514-3523. (IF=5.3) 31.Y Sun, H Gao,* Y-W Yang, A Wang, G Wu, Y Wang, Yu Fan, J Ma,Layer-by-layer supramolecular assemblies based on linear and star-shaped poly(glycerol methacrylate)s for doxorubicin delivery. J Biomed Mater Res Part A, 2013, 101A: 2164-2173.(IF=2.6) 32.A Wang, H Gao,* Y Sun, Y-L Sun, Y-W Yang, G Wu , Y Wang , Y Fan, J Ma, *Temperature- and pH-responsive nanoparticles of biocompatible polyurethanes for doxorubicin delivery. Int J Pharm,2013,441, 30-39. (IF=3.2) 33.W Gu, Y Ma, C Zhu, B Chen, J Ma, H Gao,* Synthesis of cross-linked carboxyl poly(glycerol methacrylate) and its application for the controlled release of doxorubicin.Eur J Pharm Sci,2012, 47 (3), 556-563. (IF=3.2) 34.H Gao, M Elsabahy, E Giger, D Li, R Prud’homme, J-C Leroux, Self assembling properties of aminated poly(glycerol methacrylate)s. J controlled release, 2012, 152, e142-143. (IF=5.7) 35.Y N Ma, HGao,* W Gu, Y Yang, Y Wang, Y Fan, G Wu, J Ma, Carboxylated poly(glycerol methacrylate)s for doxorubicin delivery. Eur J Pharm Sci,2012, 45, 65-72. (IF=3.3) 36.X Y Lu, H Gao,* C Li, Y Yang, Y Wang, Y Fan, G Wu, J Ma. Polyelectrolyte complex nanoparticles of amino poly(glycerol methacrylate)s and insulin, Int J Pharm, 2012, 423, 195-201. (IF=3.6) 37.H Gao, Lu X Y, Y N Ma, Y W Yang, J F Li, G L Wu, Y N Wang, Y G Fan, and Ma J B*. Amino poly(glycerol methacrylate)s for oligonucleic acid delivery with enhanced transfection efficiency and low cytotoxicity,Soft Matter, 2011, 7: 9239-9247. （IDS Number: 822YE , IF=4.6）； 38.H Gao,* Y N Ma, X Y Lu, Y R Liang, B Q Chen, and J B Ma. PH-responsive nano-assemblies of amino poly(glycerol methacrylate),Eur Pol J, 2011, 47:1232-1239（IDS Number: 776GX, IF=2.9）； 39.H G Fu, H Gao,* G L Wu, Y N Wang, Y G Fan, and J B Ma. Preparation and tunable temperature-sensitivity of biodegradable polyurethane nanoassemblies from diisocyanate and poly(ethylene Glycol), Soft Matter, 2011, 7: 3546-3552（IDS Number: 738XZ, IF=4.6）； 40.X K Sun, H Gao,* G L Wu, Y N Wang, Y G Fan, and J B Ma. Biodegradable and temperature-responsive polyurethanes for adriamycin delivery, Int J Pharm, 2011,412:52-58（IDS Number: 793EH, IF=3.0）； 41.H. Gao, M. Elsabahy, E.V. Giger, D.K. Li,R.E. Prud’homme, J.C. Leroux, Aminated linear and star-shape poly(glycerol methacrylate)s: synthesis and self-assembling properties, Biomacromolecules, 2010, 11: 889-895.（IDS Number: 581WW, IF=5.8）； 42.J. Leblond,; H. Gao, A. Petitjean, Leroux, J.C. Leroux, pH-Responsive molecular tweezers,J Am Chem Soc, 2010, 132：8544-8545. （IDS Number:, IF=8.6）； 43.H. Gao, M.-C. Jones, J. Chen, Y.R. Liang, R. E. Prud’homme, J.-C. Leroux, Hydrophilic nanoreservoirs embedded into polymeric nanoparticles - An approach to compatibilize polar molecules with hydrophobic matrices. Chem Mater,2008; 20: 4191–4193. （IDS Number: 321BM, IF=8.5）； 44.H. Gao, M.-C. Jones, J. Chen, R. E. Prud’homme, J.-C. Leroux, Core cross-linked reverse polymeric micelles. Chem Mater, 2008; 20: 3063–3067. （IDS Number: 297NM, IF=8.5）； 45.M.-C. Jones, H. Gao, J.-C. Leroux, Reverse polymeric micelles for pharmaceutical applications. J. Controlled release, 2008;132:208-215. （IDS Number: 386SL, IF=7.3）； 46.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Ethylenediamino bridged bis(β-cyclodextrin)/ poly(DL-lactic-co-glycolic acid) nanoparticles prepared by modified double emulsion method: effect of polyvinyl alcohol on nanoparticle properties. J Appl Polym Sci, 2008; 107: 571–576. （IDS Number: 229RP, IF=1.2）； 47.H. Gao, M.-C. Jones, P. Tewari, M. Ranger, J.-C. Leroux, Star-Shaped alkylated poly (glycerol methacrylate) reverse micelles: synthesis and evaluation of their solubilizing properties in dichloromethane. J Polym Sci Part A: Polym Chem, 2007; 45:2425-2435. （IDS Number: 173SZ, IF=4.0）； 48.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Conjugates of poly(DL-lactide-co-glycolide) on amino cyclodextrins and their nanoparticles as protein delivery system. J Biomed Mater Res Pt A,2007; 80A:111-122. （IDS Number: 114PN, IF=2.8）； 49.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Conjugates of poly(DL-lactic acid) with ethylenediamino or diethylenetriamino bridged bis(beta-cyclodextrin)s and their nanoparticles as protein delivery systems. J control release, 2006; 112:301-311. （IDS Number: 057NA, IF=7.3）； 50.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Interactions of some modified mono- and bis-beta-cyclodextrins with bovine serum albumin. Bioorgan & Med Chem, 2006; 14:131-137. （IDS Number: 989YB, IF=2.8）； 51.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Synthesis of a biodegradable tadpole-shaped polymer via the coupling reaction of polylactide onto mono(6-(2-aminoethyl) amino-6-deoxy)- β -cyclodextrin and its properties as the new carrier of protein delivery system. J control release, 2005; 107:158-173.（IDS Number: 970YW, IF=7.3） 专著: 1. 功能高分子材料，马建标主编，之第九章医用高分子材料， 第二版：化学工业出版社,2010年. 专利： 52.高辉; 孙现科; 马建标。具有pH响应性的生物降解聚氨酯材料的制备方法，ZL201010511225.5（已授权）。 53.高辉; 顾文星; 马亚男; 陆学友; 马建标。一种具有pH响应性聚甲基丙烯酸甘油酯的制备方法，ZL201110282730.1（已授权） 54.高辉；朱明冉。一种基于油相的两亲性高分子反相微乳的制备方法，201310454392.4 55.高辉；顾文星；王立志；郭盼。一种准嵌段共聚物反相高分子胶束的制备方法，201310420819.9 获奖: 1．马建标、王亦农、王小红、高辉、范云鸽，天然生物高分子的修饰及其生物医学性能（2010ZR-3-006）天津市自然科学三等奖（2010年）； 指导学生获得 1）第二届“天津市大学生创新、创业奖学金”顾文星获得“创新奖学金”优秀奖。 2）第十二届“挑战杯”全国大学生课外学术科技作品竞赛三等奖，天津市大学生课外学术科技作品竞赛特等奖：高分子的pH响应性能及其对抗癌药物的控制释放。人员：顾文星，朱楚宇、许祥、宋婧怡、王新雷 3）第八届中国青少年科技创新奖顾文星 |
